Berberine is a Multi-potent Anti-Alzheimer’s Weapon

Berberine is as near to an armamentarium as you can get 
for addressing the diseases of accelerated aging

A 2011 study also concluded that “berberine helps prevent oxidation damage to biomolecules in the brain, inhibits enzymes which breakdown important memory molecules, reduces peptides that interfere with proper memory function, and lowers lipids that interfere with cerebral blood flow” (19).

Accelerated aging is a new term that is circulating in the longevity community. Essentially, it refers to a disease in which various tissues, organs, or systems of the human body age prematurely. Each accelerated aging disease displays different aspects of aging, yet never every aspect. Consequently, biogerontologists often call such diseases segmental progerias.* One of these is the disease known as Alzheimer’s (DA), which has become one of the most threatening diseases in the elderly. DA accelerates aging of the mind.

*Progeria (also known as Hutchinson–Gilford Progeria Syndrome) is an extremely rare genetic condition wherein symptoms resembling multiple aspects of aging are manifested at an early age.

In medicine, an armamentarium is the collection of resources that comprise the material and equipment used by healthcare professionals in their practices. There has been no truly efficient therapeutic agent to combat DA, let alone an armamentarium. That said, a growing body of knowledge about the plant derivative berberine is finding that this natural isoquinoline alkaloid possesses a wide range of pharmacological effects, and in fact is as near to an armamentarium as you can get with regard to diseases of accelerating aging, including DA.

Alzheimer’s accelerates 
aging of the mind.

In a new study, conducted at Shandong University of Technology in China, researchers have reviewed berberine’s multiple activities including its antioxidant, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory, monoamine oxidase inhibitory, amyloid-beta (Aβ) peptide-level reducing, and cholesterol-lowering activities.1 In other words, berberine helps prevent oxidation damage to biomolecules in the brain, inhibits enzymes which breakdown important memory molecules, reduces peptides that interfere with proper memory function, and lowers lipids that interfere with cerebral blood flow. Together, these capacities suggest that berberine may act as a promising multipotent agent to combat DA, one of the most threatening diseases in the elderly with the accelerated aging of human society.

Berberine is isolated from the herb Rhizoma coptidis, which has been widely used in Chinese herbal medicine. It is also found in such plants as Berberis [e.g. Berberis aquifolium (Oregon grape), Berberis vulgaris (Barberry), and Berberis aristata(Tree Turmeric)], Hydrastis canadensis (Goldenseal), Phellodendron amurense (Amur Cork Tree, Huang Bai, Huang Po, Po Mu), Coptis chinensis (Chinese Goldthread, Huang-Lian, Huang-Lien), and Tinospora cordifolia, as well as other plants. Berberine is usually found in the roots, rhizomes, stems, and bark.

 Berberine For Depression

One of the Berberine benefits is that it may be able to help with depression. So far the research has only been conducted on mice and rats, but the studies have shown that Berberine is able to increase the levels of Serotonin, Dopamine, and Norepinephrine in the brain (20 -21).

Also, inflammation has also been linked to the development of depressive symptoms, and because Berberine can reduce inflammation in the body, this may also be another mechanism through which it can act against the symptoms of depression.

Berberine on Longevity

1 DECEMBER 2017 Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation

Aging is the greatest risk factor for human diseases, as it results in cellular growth arrest, impaired tissue function and metabolism, ultimately impacting life span. Two different mechanisms are thought to be primary causes of aging. One is cumulative DNA damage induced by a perpetuating cycle of oxidative stress; the other is nutrient-sensing adenosine monophosphate-activated protein kinase (AMPK) and rapamycin (mTOR)/ ribosomal protein S6 (rpS6) pathways. As the main bioactive component of natural Chinese medicine berberine has recently been reported to expand life span and attenuate premature cellular senescence. 

 

 

 

 

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Berberine For Non-Alcoholic Fatty Liver Disease

 

Fatty Liver Disease is a risk factor for people suffering from type 2 diabetes, PCOS, and also people who are overweight, have high cholesterol and high blood pressure. Current medications such as Metformin and Pioglitazone have limited success in treating the condition.

Studies on Berberine, however, have shown it can improve liver function, increase fatty acid burning in the liver, decrease glucose production in the liver, and reduce fat build-up in the liver (23 -24).

A more recent study in 2015 showed that Berberine improves fatty liver disease and that Berberine could act on liver genes to change how they expressed themselves to improve fat storage and fat burning in the liver (25).

 

Berberine+ is one the most effective natural supplements available with impressive health benefits that affect your body at the molecular level. Berberine+ is a cutting edge formula that helps control blood sugar, weight management and supports:

-anti-aging factors associated with with Longevity

-heart health

-treatment of fatty liver disease

-Cardiovascular and Liver health

-Healthy body fat

 Berberine For Arthritis and Joint Health

Berberine’s powerful anti-inflammatory properties could well benefit people suffering from rheumatoid arthritis and joint problems. So far the research is still in the early stages, but it is promising. A recent study published in the journal Inflammation conducted on an animal model of rheumatoid arthritis (known as CIA) found that berberine reduced arthritic scores and the immune response in rats (arthritis is an auto-immune condition, where the immune system attacks the body) (26). We eagerly await more studies!

Berberine to Boost the Immune System

As we’ve seen, Berberine fights parasites, viruses, and fungi. It also helps rebalance the gut and reduce the number of bad bacteria (15). It can even fight against infection with superbugs like MRSA (16). All in all, it is an excellent supplement for boosting the immune system!

 

  • Studies show Cinnamon may increase insulin sensitivity and decrease blood sugar - both key components for losing weight and controlling type 2 diabetes.1 
  • Cinnamon is also thought to boost metabolism because your body uses more energy to process the spice than it does for other foods.
  • It’s full of fiber, a nutrient that’s essential for achieving that “full” feeling and signaling to your body that mealtime is over. 

 

Cinnamon is an easy, natural way to promote healthy blood sugar levels!** Cinnamon is a powerful wellness herb for the body's digestive and circulatory systems, where it aids in regulating the metabolism of sugars and fats.** Cinnamon is most commonly used to balance blood sugar levels and optimize the performance of insulin.** Made from the finest-quality cinnamon tree bark and delivered directly to your door, Berberine+ is an excellent value supplement for anyone seeking to maintain healthy blood sugar levels.**

BLOOD-SUGAR SUPPORT FOR BOTH KETO & NON-KETO DIETERS — Berberine+ has been shown to improve blood sugar. BERBERINE, CINNAMON and PATENTED BIOPERINE work synergistically in perfect sync to provide a powerful combination of blood-sugar support for all dieters. 

Berberine is a bitter yellow plant alkaloid that has a long history in Chinese and Ayurvedic medicine. Berberine has over 3000 years of medicinal use around the world. Modern Science have now clearly identified Berberine’s therapeutic mechanism of action and its benefits. One of berberine’s mind blowing mechanisms of action is supporting activation of an enzyme called AMPK which works as a master switch in body that controls cellular metabolism.

Berberine+ contains two types of cinnamon which are powerful natural antioxidant that supports glucose metabolism, brain function, healthy blood pressure and cardiovascular health. Ceylon cinnamon also supports metabolism of fat, sugar and starches to promote healthy blood sugar levels and aids in weight management.

BERBERINE+ ACTIVE INGREDIENTS WORK IN SYNERGY TO HELP LOWER IGF1; taking sugar from the blood to the muscles to be used as fuel, promoting optimal blood glucose levels, support optimizing insulin respond and anti-aging, mechanisms very similar to Fasting, ketogenic diet and the drug metformin.

 Berberine Benefits For Candida

Candida is a yeast found in our gut, skin, and mouth. Small amounts of it are necessary to help us digest our food, but when there is an overgrowth it can cause problems and is it tricky to treat. An overgrowth of Candida can cause a breakdown of our intestinal wall leading to the release of toxic byproducts into the body, known as leaky gut.

Its symptoms can range from a fungal nail and skin infections to eczema, ADHD, depression, and anxiety. It may even make you crave carbohydrates. Tackling Candida should never just be left to one thing, it takes a multi-pronged ‘attack’ to reverse Candida overgrowth.

However, Berberine is an excellent part of a Candida cleansing program. Berberine has fantastic anti-microbial activity and can:

  • Increase the activity of more powerful antifungals like caprylic and undecylenic acid
  • Kill other bad bacteria and parasites that may be contributing to Candida overgrowth
  • Support the mucous membranes of the throat, digestive system and vagina and support the immune system which will counteract the opposite effect of strong fungi
  • Help support liver function and bile secretion
  • Help the gut replenish good bacteria after a period of taking antibiotics.

Berberine can also act specifically against Candida albicans. A 2011 study showed that Berberine could directly inhibit the growth of various Candida species, and it’s action also increased the effectiveness of antimycotics or antifungal drugs (12).

 Berberine For SIBO – Small Intestine Bacterial Overgrowth

SIBO is an overgrowth of bacteria in the small intestine and can lead to abdominal pain, bloating, gas and diarrhea. It may also lead to vitamin and mineral deficiencies and weight loss

Current medical treatments focus mainly on antibiotic treatment, although these have negative side effects as both good and bad bacteria are killed off, which is why many people are turning to traditional herbal remedies for a cure. Because Berberine has such strong anti-bacterial abilities it’s a good alternative treatment for those who don’t want to take, or who have not had success with oral antibiotics.

Berberine has been shown to be effective against gram-positive bacterial strains which are predominant in the small intestine (13). Also, herbal remedies have been shown to be at least as effective, and sometimes more effective than antibiotic treatments against SIBO such as Rifaximin. For example, a 2014 study showed 46% of the patients who took herbal ‘antibiotics’ had a negative breath test for SIBO after treatment, compared to just 34% of the Rifaximin users.

Berberine For Acne

Berberine has an antilipogenic effect on the sebaceous glands, so it can help people suffering from acne. Research has shown that in cases of moderate to severe acne a dose of 600mg per day was able to improve symptoms by as much as 45% after only 4 weeks, (acne symptoms were measure by counting non-inflamed, inflamed, and total acne lesions, as well as using the Michaelson’s acne severity score) (5).

Also, one of the Berberine benefits is that it can speed the healing of acne scars and can prevent future outbreaks of acne.

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MORE ON THE SCIENCE BEHIND BERBERINE+

Berberine has been tested and used successfully in experimental and human diabetes mellitus, both type 2 and type 1 (see “Berberine Gives Diabetes the 1–2 Punch” in the August issue). In this metabolic disease, it has been shown to lower elevated blood glucose as effectively as metformin. Berberine works in several ways. First, by inhibiting of aldose reductase, it induces glycolysis, thus preventing insulin resistance by increasing insulin receptor expression and acting like incretins (gastrointestinal hormones that cause an increase in the amount of insulin). One new study proffered the idea that berberine may overcome insulin resistance via modulating key molecules in the insulin signaling pathway, leading to increased glucose uptake in insulin-resistant cells. In this way, berberine may modulate glucokinase activity, rendering pancreas β cells more sensitive to glucose fluctuation and to respond more effectively to glucose challenge.

As well, berberine seems to inhibit hyperglycemic factors and suppress intestinal disaccharidases with beneficial metabolic effects in diabetic states. A recent comprehensive metabolic analysis applied to 60 type 2 diabetics suggested that the administration of berberine down-regulates the high level of free fatty acids, which are known to be toxic to the pancreas and cause insulin resistance. Also, berberine has been shown to boost the effects of the diabetic drugs metformin and 2,4-thiazolidinedione (THZ), and can partly replace these commercial drugs, which could lead to a reduction in toxicity and side effects associated with the drugs.

Then, berberine inhibits FoxO1, which integrates insulin signaling with mitochondrial function. FoxO1 is a member of the forkhead family of transcription factors and among its functions, it is believed to induce insulin resistance. Inhibition of FoxO1 can improve hepatic metabolism during insulin resistance and the metabolic syndrome.

Berberine, also known as berberine hydrochloride and isoquinoline alkaloid, is a major alkaloid from Coptis chinensis. Berberine's extensive biological properties have previously been studied, and it has been used clinically for the treatment of hypertension, diabetes and other diseases. The present study aimed to determine the possible anticancer effects of berberine hydrochloride treatment on human non-small cell lung cancer (NSCLC) cell proliferation and apoptosis via the matrix metalloproteinase 2 (MMP-2) and the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax) signaling pathway. Human A549 lung carcinoma cells were exposed to various concentrations of berberine hydrochloride in order to analyze the possible anticancer effects on NSCLC cell proliferation and apoptosis, using a MTT assay and an Annexin V-fluorescein isothiocyanate/propidium iodide apoptosis kit. Subsequently, the present study detected the expression of MMP-2, Bcl-2, Bax and Janus kinase 2 (Jak2). Berberine hydrochloride treatment inhibited the expression of vascular endothelial growth factor (VEGF) and nuclear factor κB (NF-κB) and transcription factor AP-1 (AP-1) proteins, in A549 cells. Firstly, it was revealed that berberine hydrochloride treatment may inhibit proliferation, increase cytotoxicity and enhance apoptosis in A549 cells. Subsequently, treatment with berberine hydrochloride significantly downregulated MMP-2 protein expression, increased the activity of the Bcl-2/Bax signaling pathway and suppressed the Jak2/VEGF/NF-κB/AP-1signaling pathways. These results suggest that berberine hydrochloride may be a potential novel anticancer drug, since it inhibits cell proliferation and promotes the rate of apoptosis of NSCLC cells by the suppression of the MMP-2, Bcl-2/Bax and Jak2/VEGF/NF-κB/AP-1 signaling pathways.

 

How Does Berberine Help PCOS?

Berberine lowers insulin and blood glucose levels in a similar way to Metformin, which is often prescribed for PCOS. Berberine up-regulates the expression of insulin receptor genes in cells, allowing them to absorb glucose at lower insulin levels, so we don’t have to produce as much. It also prevents digestion of carbohydrates in the diet, reduces the production of glucose in the liver, and reduces the levels of bad bacteria in the gut, which reduces inflammation.

Berberine also directly inhibits inflammatory pathways including TNF alpha, interleukin-6, and COX2. Inflammation has a key role in PCOS, and most women suffering from it have some level of chronic inflammation. Berberine also reduces testosterone production in the theca cells of the ovaries (4) and helps reduce fat accumulation in the liver. Again many women suffering from PCOS also suffer from fatty liver disease. Berberine can also help women suffering from acne because testosterone excess is another facet of PCOS (5).

 

References

(1) Jing Yang, Jinhua Yin, Hongfei Gao, Linxin Xu, Yan Wang, Lu Xu and Ming Li 2 , Published online 2012 Mar 8.Berberine Improves Insulin Sensitivity by Inhibiting Fat Store and Adjusting Adipokines Profile in Human Preadipocytes and Metabolic Syndrome Patients, Evid Based Complement Alternat Med. 2012; 2012: 363845.

(2) Zhang Z1, Zhang H1, Li B1, Meng X2, Wang J1, Zhang Y1, Yao S1, Ma Q1, Jin L1, Yang J1, Wang W1, Ning G1, Berberine activates thermogenesis in white and brown adipose tissue, Nat Commun. 2014 Nov 25;5:5493.

(3) Yueshan Hua, b, , , Erik A. Ehlia, b, Julie Kittelsrudc, Patrick J. Ronanb, c, Karen Mungerc, Terry Downeyc, Krista Bohlenc, d, Leah Callahanc, Vicki Munsonc, Mike Jahnkec, Lindsey L. Marshalle, Kelly Nelsona, Patricia Huizengaa, Ryan Hansena, c, Timothy J. Soundyb, Gareth E. Daviesa, b, Lipid-lowering effect of berberine in human subjects and rats, Phytomedicine

Volume 19, Issue 10, 15 July 2012, Pages 861–867

(4) Zhao L, Li W et al. Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro. Fertil Steril. 2011 ;95(1):461-3.

(5) Fouladi RF, Aqueous extract of dried fruit of Berberis vulgaris L. in acne vulgaris, a clinical trial. J Diet Suppl. 2012 Dec;9(4):253-61.

(6) Wei W, Zhao H, Wang A, et al. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol. 2012

(7) An Y, Sun Z, Zhang Y, et al. The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment. Clin Endocrinol. 2014;80(3):425-31.

(8) Dong H, Zhao Y, Zhao L, Lu F, The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials, Planta Med. 2013 Apr;79(6):437-46.

(9) Farzad Shidfar,a,* Shima Seyyed Ebrahimi,a Sharieh Hosseini,b Iraj Heydari,c Shahrzad Shidfar,d, and Giti Hajhassanie, The Effects of Berberis vulgaris Fruit Extract on Serum Lipoproteins, apoB, apoA-I, Homocysteine, Glycemic Control and Total Antioxidant Capacity in Type 2 Diabetic Patients, Iran J Pharm Res. 2012 Spring; 11(2): 643–652.

(10) Cicero AF1, Rovati LC, Setnikar I, Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation, Arzneimittelforschung. 2007;57(1):26-30.

(11) Flora Affuso, Valentina Mercurio, Valeria Fazio, and Serafino Fazio,Cardiovascular and metabolic effects of Berberine, World J Cardiol. 2010 Apr 26; 2(4): 71–77.

(12) Wei GX1, Xu X, Wu CD, In vitro synergism between berberine and miconazole against planktonic and biofilm Candida cultures, Arch Oral Biol. 2011 Jun;56(6):565-72.

(13) Cernáková M1, Kostálová D, Antimicrobial activity of berberine–a constituent of Mahonia aquifolium, Folia Microbiol (Praha).

(14) Chedid V1, Dhalla S2, Clarke JO3, Roland BC4, Dunbar KB5, Koh J6, Justino E7, Tomakin E8, Mullin GE9, Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth, Glob Adv Health Med. 2014 May;3(3):16-24.

(15) Han J, Lin H, & Huang W (2011). Modulating gut microbiota as an anti-diabetic mechanism of berberine. Medical Science Monitor 17.

(16) Yu H1, Kim KJ, Cha JD, Kim HK, Lee YE, Choi NY, You YO, Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus,J Med Food. 2005 Winter;8(4):454-61.

(17) Wu Y, Li JQ, Kim YJ, Wu J, Wang Q, Hao Y, In vivo and in vitro antiviral effects of berberine on influenza virus, Chin J Integr Med. 2011 Jun;17(6):444-52.

(18) Jiang W, Li S, Li X, Therapeutic potential of berberine against neurodegenerative diseases, Sci China Life Sci. 2015 Jun;58(6):564-9.

(19) Ji HF, Shen L, Berberine: a potential multipotent natural product to combat Alzheimer’s disease, Molecules. 2011 Aug 9;16(8):6732-40.

(20) Kulkarni SK1, Dhir A, On the mechanism of antidepressant-like action of berberine chloride, Kulkarni SK1, Dhir A, Eur J Pharmacol. 2008 Jul 28;589(1-3):163-72.

(21) Peng WH, Lo KL, Lee YH, Hung TH, Lin YC, Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice, Life Sci. 2007 Aug 23;81(11):933-8. Epub 2007 Aug 16.

(22) Lin K1, Liu S, Shen Y, Li Q, Berberine attenuates cigarette smoke-induced acute lung inflammation, Inflammation. 2013 Oct;36(5):1079-86.

(23) Kim WS, Lee YS, Cha SH, Jeong HW, Choe SS, Lee MR, Oh GT, Park HS, Lee KU, Lane MD, Kim JB, Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity, Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E812-9.

(24) Yang Liu, Li Zhang, Haiyan Song, and Guang Ji, Update on Berberine in Nonalcoholic Fatty Liver Disease, Evidence-Based Complementary and Alternative Medicine Volume 2013 (2013).

(25) Xinlu Yuan, Jie Wang, Xiaoyan Tang, Yixue Li, Pu Xia and Xin Gao, Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles, Journal of Translational Medicine201513:24

(26) Wang Z, Chen Z, Yang S, Wang Y, Huang Z, Gao J, Tu S, Rao Z, Berberine ameliorates collagen-induced arthritis in rats associated with anti-inflammatory and anti-angiogenic effects, Inflammation. 2014 Oct;37(5):1789-98. https://www.ncbi.nlm.nih.gov/pubmed/24803296